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Severe acute respiratory syndrome coronavirus accessory protein 6 is a virion-associated protein and is released from 6 protein-expressing cells.

Identifieur interne : 003593 ( Main/Exploration ); précédent : 003592; suivant : 003594

Severe acute respiratory syndrome coronavirus accessory protein 6 is a virion-associated protein and is released from 6 protein-expressing cells.

Auteurs : Cheng Huang [États-Unis] ; C J Peters ; Shinji Makino

Source :

RBID : pubmed:17344286

Descripteurs français

English descriptors

Abstract

Analysis of severe acute respiratory syndrome coronavirus (SCoV) by either sucrose gradient equilibrium centrifugation or a virus capture assay using an anti-SCoV S protein antibody demonstrated that the SCoV 6 protein, which is one of the accessory proteins of SCoV, was incorporated into virus particles. Coexpression of the SCoV S, M, E, and 6 proteins was sufficient for incorporation of the 6 protein into virus-like particles. Cells transfected with plasmid expressing the 6 protein released SCoV 6 protein; however, infected cells released SCoV 6 protein only in association with SCoV particles.

DOI: 10.1128/JVI.02307-06
PubMed: 17344286


Affiliations:


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